Notch signaling

Dr. Dang is studying the anti-tumor effect of gamma-secretases inhibitors, compounds that inhibit activation of the Notch pathway that is active in lung cancer cells. She is studying its effect both alone and in combination with traditional chemotherapy and targeted therapy.

Dr. Chandel is working to identify novel pathways underlying KRAS-driven lung cancer. He is testing two pathways, to determine how mitochondria (powerhouses of the cell) and Notch signaling (a pathway often activated in lung cancer that relays information from outside the cell to inside) behave differently in cancer and non-cancer cells.