Chemoprevention

The process of preventing the development of cancer by using drugs or lifestyle modifications

Inflammation-Related Lung Cancer Prevention by Targeting the NF-kB Pathway

American Lung Association/LUNGevity Foundation Discovery Award
Seyed Javad Moghaddam, MD
University of Texas MD Anderson Cancer Center
Houston

Dr. Moghaddam is investigating how airway inflammation can lead to lung cancer.  The factor NF-κβ is involved in both inflammation and carcinogenesis. Dr. Moghaddam’s hypothesis is that NF-κβ is a likely candidate for the promotion of lung cancer by inflammation in chronic obstructive pulmonary disease patients.

Biomarkers for targeted lung cancer chemoprevention

Meredith Tennis, PhD
University of Colorado Denver
Denver

Dr. Tennis aims to identify biomarkers that signal whether a patient is likely to benefit from iloprost and pioglitazone, two drugs that have demonstrated promise in reducing NSCLC risk, and determine whether they work in a clinical trial setting.