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Dr. Klinge is studying why there is a gender bias in lung adenocarcinoma that results in women being at higher risk for developing it. Her studies have revealed which proteins are expressed differently by gender in lung adenocarcinoma cells and how they could be targets of therapy in lung adenocarcinoma.

Previous work of Dr. Eaton and colleagues has demonstrated that mice vaccinated with certain stem cells are 80%-90% protected against the growth of lung tumors injected into the mice as well as protected against the development of lung cancer caused by administration of a carcinogen. The current research is determining whether lung cancer stem cells are selectively destroyed by lymphocytes (immune cells) from vaccinated mice. Dr. Eaton is also determining whether stem cell vaccination  affects the growth of lung tumors in mice that have been genetically engineered to spontaneously develop lung cancer.